CAR-T cell therapy, once known primarily for its breakthroughs in cancer treatment, is now making promising strides in the field of autoimmune diseases. This category explores the latest research, clinical progress, and real-world applications of CAR-T therapy in treating conditions such as lupus, multiple sclerosis, rheumatoid arthritis, and more. Discover how Chinese researchers and biotech innovators are pushing the boundaries of immunotherapy—reprogramming T cells to reset the immune system and achieve long-lasting remission in patients with severe autoimmune disorders. Stay informed on the transformative potential of CAR-T as it reshapes the future of autoimmune disease management.
A Phase 1 clinical study demonstrates that dual-target BCMA-CD19 CAR-T therapy (ICG318) can achieve sustained, drug-free remission and significant renal improvement in patients with refractory SLE and lupus nephritis, with follow-up extending up to six years.
A new study reveals that off-the-shelf CD19-targeted CAR-T cell therapy effectively treats relapsed systemic lupus erythematosus (SLE), achieving remission and kidney recovery. Discover how this innovative approach may revolutionize autoimmune disease treatment.
Recently, a clinical study on “Targeted CD19 Chimeric Antigen Receptor T-Cell Therapy for Refractory Pediatric Systemic Lupus Erythematosus” has been successfully completed with the 20th patient undergoing CAR-T cell infusion.
Dr. Xu Huji becomes a Nature 2024 Top 10 Scientist for developing the world’s first universal CAR-T therapy for autoimmune diseases—marking a breakthrough in low-cost, scalable immunotherapy.
Breakthrough study in China shows off-the-shelf CAR-T therapy can reverse severe autoimmune disease, offering faster, safer, and more affordable treatment.
CAR T-cell therapy shows promise in treating refractory autoimmune rheumatic diseases by targeting CD19 for faster, more significant effects and potential drug-free remission.
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